THE TRAIN DELAY MODEL DEVELOPED BY THE GENETIC PROGRAMMING ALGORITHM




The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.

PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL).It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block and malignant transformation of hematopoietic cells.Here, we found that mice primary hematopoietic progenitor cells (HPCs), transduced by DNA-binding-defec

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